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Inside Cover: Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasA p ) Bound to Synthetic Metal Complexes (Angew. Chem. Int. Ed. 11/2014)
Author(s) -
Shirataki Chikako,
Shoji Osami,
Terada Mitsuyoshi,
Ozaki Shinichi,
Sugimoto Hiroshi,
Shiro Yoshitsugu,
Watanabe Yoshihito
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401090
Subject(s) - pseudomonas aeruginosa , int , heme , chemistry , metal , stereochemistry , phthalocyanine , biochemistry , biology , bacteria , organic chemistry , enzyme , genetics , computer science , operating system
The secreted heme acquisition protein of P. aeruginosa (HasA p ), which is shaped like a fish, was found to be able to capture various synthetic iron complexes, such as iron–salophen and iron–phthalocyanine. In their Communication on page 2862 ff. , O. Shoji, Y. Watanabe, and co‐workers demonstrate the effect of HasA p bound to these unnatural iron complexes on the growth of P. aeruginosa and show that HasA p bound to iron–phthalocyanine inhibits HasA p ‐mediated iron acquisition.