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Back Cover: Engineering of P450pyr Hydroxylase for the Highly Regio‐ and Enantioselective Subterminal Hydroxylation of Alkanes (Angew. Chem. Int. Ed. 12/2014)
Author(s) -
Yang Yi,
Liu Ji,
Li Zhi
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401084
Subject(s) - enantiopure drug , enantioselective synthesis , hydroxylation , chemistry , stereoselectivity , directed evolution , biocatalysis , catalysis , enzyme , stereochemistry , regioselectivity , organic chemistry , combinatorial chemistry , biochemistry , ionic liquid , gene , mutant
P450 enzymes that were obtained by the directed evolution of terminal‐selective P450pyr hydroxylase enabled the first highly regio‐ and enantioselective subterminal hydroxylation of an alkane at a non‐activated carbon atom, as described by Z. Li and co‐workers in their Communication on page 3120 ff. The engineered P450 enzymes are useful catalysts for the regio‐ and stereoselective functionalization of alkanes and the preparation of enantiopure alcohols.