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Inside Back Cover: Controlling Biological Activity with Light: Diarylethene‐Containing Cyclic Peptidomimetics (Angew. Chem. Int. Ed. 13/2014)
Author(s) -
Babii Oleg,
Afonin Sergii,
Berditsch Marina,
Reiβer Sabine,
Mykhailiuk Pavel K.,
Kubyshkin Vladimir S.,
Steinbrecher Thomas,
Ulrich Anne S.,
Komarov Igor V.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401081
Subject(s) - peptidomimetic , diarylethene , chemistry , biophysics , photochromism , peptide , photochemistry , biology , biochemistry
A photoswitchable analogue of the cyclic antimicrobial peptide gramicidin S was created by using a reversibly photoisomerizable diarylethene scaffold. In their Communication on page 3392 ff., A S. Ulrich, I V. Komarov, and co‐workers show that the biological activity of the resulting peptidomimetic could be effectively controlled by ultraviolet/visible light, as illustrated by a bacterial lawn treated with the modified gramicidin S and illuminated through a mask.