Premium
Cover Picture: Total Synthesis of Resveratrol‐Based Natural Products Using a Palladium‐Catalyzed Decarboxylative Arylation and an Oxidative Heck Reaction (Angew. Chem. Int. Ed. 9/2014)
Author(s) -
Klotter Felix,
Studer Armido
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400659
Subject(s) - click chemistry , chemistry , resveratrol , aryl , heck reaction , combinatorial chemistry , oxidative phosphorylation , palladium , catalysis , biochemistry , organic chemistry , alkyl
Resveratrol‐based natural products can be selectively synthesized by a novel highly modular approach. In their Communication on page 2473 ff., A. Studer and F. Klotter report the use of Pd‐catalyzed decarboxylative arylation and an oxidative Heck reaction to introduce structurally important aryl groups to a common building block, which is readily available on a large scale. The modular approach is convincingly documented by the syntheses of quadrangularin A, ampelopsin D, and pallidol.