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Fabrication of Multiresponsive Bioactive Nanocapsules through Orthogonal Self‐Assembly
Author(s) -
Yeh YiCheun,
Tang Rui,
Mout Rubul,
Jeong Youngdo,
Rotello Vincent M.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400559
Subject(s) - nanocapsules , supramolecular chemistry , self assembly , nanotechnology , cationic polymerization , amphiphile , nanoparticle , fluorescence , fabrication , chemistry , rational design , materials science , combinatorial chemistry , polymer , copolymer , molecule , organic chemistry , medicine , physics , alternative medicine , pathology , quantum mechanics
Multifunctional self‐assembled systems present platforms for fundamental research and practical applications as they provide tunability of structure, functionality, and stimuli responsiveness. Pragmatic structures for biological applications have multiple design requirements, including control of size, stability, and environmental response. Here we present the fabrication of multifunctional nanoparticle‐stabilized capsules (NPSCs) by using a set of orthogonal supramolecular interactions. In these capsules, fluorescent proteins are attached to quantum dots through polyhistidine coordination. These anionic assemblies interact laterally with cationic gold nanoparticles that are anchored to the fatty acid core through guanidinium–carboxylate interactions. The lipophilic core then provides a reservoir for hydrophobic endosome‐disrupting agents, thereby generating a system featuring stimuli‐responsive release of a payload into the cytosol with fluorescence monitoring.