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Protein Interactions with Polymer Coatings and Biomaterials
Author(s) -
Wei Qiang,
Becherer Tobias,
AngiolettiUberti Stefano,
Dzubiella Joachim,
Wischke Christian,
Neffe Axel T.,
Lendlein Andreas,
Ballauff Matthias,
Haag Rainer
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400546
Subject(s) - protein adsorption , nanotechnology , adsorption , biomedicine , monolayer , materials science , polymer , protein–protein interaction , biochemical engineering , chemistry , computer science , engineering , bioinformatics , organic chemistry , biochemistry , biology
Abstract Protein adsorption is considered to be the most important factor of the interaction between polymeric biomaterials and body fluids or tissues. Water‐mediated hydrophobic and hydration forces as well as electrostatic interactions are believed to be the major factors of protein adsorption. A systematic analysis of various monolayer systems has resulted in general guidelines, the so‐called “Whitesides rules”. These concepts have been successfully applied for designing various protein‐resistant surfaces and are being studied to expand the understanding of protein–material interactions beyond existing limitations. Theories on the mechanisms of protein adsorption are constantly being improved due to the fast‐developing analytical technologies. This Review is aimed at improving these empirical guidelines with regard to present theoretical and analytical advances. Current analytical methods to test mechanistic hypotheses and theories of protein–surface interactions will be discussed. Special focus will be given to state‐of‐the‐art bioinert and biospecific coatings and their applications in biomedicine.