Premium
Oxidative Cross‐Coupling of Allenyl Ketones and Organoboronic Acids: Expeditious Synthesis of Highly Substituted Furans
Author(s) -
Xia Ying,
Xia Yamu,
Ge Rui,
Liu Zhen,
Xiao Qing,
Zhang Yan,
Wang Jianbo
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400500
Subject(s) - palladium , furan , oxidative phosphorylation , carbene , chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , oxidative coupling of methane , transformation (genetics) , catalysis , materials science , biochemistry , metallurgy , gene
Allenyl ketones are employed as coupling partners in palladium‐catalyzed oxidative cross‐coupling reactions with organoboronic acids. This reaction constitutes an efficient methodology for the synthesis of highly substituted furan derivatives. Palladium‐carbene migratory insertion is proposed as the key step in this transformation.