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Inside Cover: Seamless Integration of Dose‐Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of β‐Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)
Author(s) -
Werner Michael,
Kuratli Christoph,
Martin Rainer E.,
Hochstrasser Remo,
Wechsler David,
Enderle Thilo,
Alanine Alexander I.,
Vogel Horst
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400199
Subject(s) - cover (algebra) , chemistry , drug discovery , combinatorial chemistry , computational biology , nanotechnology , computer science , biochemistry , materials science , engineering , biology , mechanical engineering
Structure–activity relationship (SAR) data is a key requirement in modern medicinal chemistry for optimization of lead molecules to drug candidates. In their Communication on page 1704 ff., M. Werner, R. E. Martin, and co‐workers demonstrate with beta‐secretase that cycle times for SAR generation can be reduced from days to 60 minutes. This accelerated process was achieved by integrating compound synthesis, purification, quantification, and biological assaying into a fully automated flow‐based system.