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Back Cover: Biomimetic RNA‐Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells (Angew. Chem. Int. Ed. 7/2014)
Author(s) -
Wang Zhongliang,
Wang Zhe,
Liu Dingbin,
Yan Xuefeng,
Wang Fu,
Niu Gang,
Yang Min,
Chen Xiaoyuan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400197
Subject(s) - gene silencing , multiple drug resistance , small interfering rna , chemistry , cytotoxic t cell , int , drug resistance , combinatorial chemistry , biophysics , nanotechnology , biology , computational biology , rna , biochemistry , gene , materials science , in vitro , genetics , computer science , operating system
Synthetic RISC‐mimic nanocomplexes for sequence‐specific gene silencing are demonstrated by X. Chen, M. Yang, et al. in their Communication on page 1997 ff. Owing to unusual cooperative interaction among the components, the nanocomplexes, which were designed to target multidrug resistance, are able to successfully restore the sensitivity of OVCAR8/ADR cells to Pgp‐transportable cytotoxic agents, and also exhibit resistance to enzymatic degradation, excellent target selectivity, and specific self‐delivery.