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Next‐Generation Heteronuclear Decoupling for High‐Field Biomolecular NMR Spectroscopy
Author(s) -
Schilling Franz,
Warner Lisa R.,
Gershenzon Naum I.,
Skinner Thomas E.,
Sattler Michael,
Glaser Steffen J.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400178
Subject(s) - heteronuclear molecule , decoupling (probability) , sideband , broadband , spectroscopy , bandwidth (computing) , nuclear magnetic resonance spectroscopy , adiabatic process , physics , materials science , computer science , chemistry , nuclear magnetic resonance , optics , quantum mechanics , telecommunications , engineering , radio frequency , control engineering
Ultra‐high‐field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low‐power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra‐low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state‐of‐the‐art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high‐field biomolecular NMR spectroscopy.