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Remote Stereocontrol Transmitted through Helicity
Author(s) -
Johnston Craig P.,
Smith Martin D.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400154
Subject(s) - foldamer , helicity , helix (gastropod) , preference , stereoselectivity , stereochemistry , physics , mathematics , chemistry , biology , quantum mechanics , biochemistry , paleontology , statistics , snail , catalysis
Near…far…wherever you are! Two chiral residues at the N‐terminus of a helical foldamer are sufficient to induce a significant helical screw‐sense preference. The capacity of this helix to transmit stereochemical information is exemplified by highly stereoselective transformations conducted over nanometer distances.