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Cationic Ir/Me‐BIPAM‐Catalyzed Asymmetric Intramolecular Direct Hydroarylation of α‐Ketoamides
Author(s) -
Shirai Tomohiko,
Ito Hajime,
Yamamoto Yasunori
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201400147
Subject(s) - cationic polymerization , intramolecular force , catalysis , chemistry , polymer chemistry , stereochemistry , organic chemistry
Asymmetric intramolecular direct hydroarylation of α‐ketoamides gives various types of optically active 3‐substituted 3‐hydroxy‐2‐oxindoles in high yields with complete regioselectivity and high enantioselectivities (84–98 % ee ). This is realized by the use of the cationic iridium complex [Ir(cod) 2 ](BAr F 4 ) and the chiral O ‐linked bidentate phosphoramidite ( R , R )‐Me‐BIPAM.