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Confining Phosphanes Derived from Cyclodextrins for Efficient Regio‐ and Enantioselective Hydroformylation
Author(s) -
Jouffroy Matthieu,
GramageDoria Rafael,
Armspach Dominique,
Sémeril David,
Oberhauser Werner,
Matt Dominique,
Toupet Loic
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201311291
Subject(s) - enantioselective synthesis , hydroformylation , chemistry , organic chemistry , catalysis , rhodium
Two confining phosphane ligands derived from either α‐ or β‐cyclodextrin produce singly P III ‐ligated metal complexes with unusual coordination spheres. High‐pressure NMR studies have revealed that rhodium hydride complexes of the same type are also formed under hydroformylation conditions. This unique feature strongly favors the formation of the branched aldehyde at the expense of the linear one with high enantioselectivity in the rhodium‐catalyzed hydroformylation of styrene.