Premium
Carbon‐Monoxide‐Releasing Molecules for the Delivery of Therapeutic CO In Vivo
Author(s) -
GarcíaGallego Sandra,
Bernardes Gonçalo J. L.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201311225
Subject(s) - corm , carbon monoxide , in vivo , hemoglobin , chemistry , nanotechnology , pharmacology , combinatorial chemistry , materials science , medicine , organic chemistry , biology , microbiology and biotechnology , agronomy , catalysis
The development of carbon‐monoxide‐releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition‐metal carbonyl complexes. Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinical development. Described in this Minireview are the methods used for CORM selection, to date, and how new insights into the reactivity of metal‐carbonyl complexes in vivo, together with advances in methods for live‐cell CO detection, are driving the design and synthesis of new CORMs, CORMs that will enable controlled CO release in vivo in a spatial and temporal manner without affecting oxygen transport by hemoglobin.