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Unprecedented Iron‐Catalyzed Ester Hydrogenation. Mild, Selective, and Efficient Hydrogenation of Trifluoroacetic Esters to Alcohols Catalyzed by an Iron Pincer Complex
Author(s) -
Zell Thomas,
BenDavid Yehoshoa,
Milstein David
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201311221
Subject(s) - pincer movement , catalysis , chemistry , trifluoroacetic acid , organic chemistry , metal , combinatorial chemistry
The synthetically important, environmentally benign hydrogenation of esters to alcohols has been accomplished in recent years only with precious‐metal‐based catalysts. Here we present the first iron‐catalyzed hydrogenation of esters to the corresponding alcohols, proceeding selectively and efficiently in the presence of an iron pincer catalyst under remarkably mild conditions.