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Omaezallene from Red Alga Laurencia sp.: Structure Elucidation, Total Synthesis, and Antifouling Activity
Author(s) -
Umezawa Taiki,
Oguri Yuko,
Matsuura Hiroshi,
Yamazaki Shohei,
Suzuki Masahiro,
Yoshimura Erina,
Furuta Takeshi,
Nogata Yasuyuki,
Serisawa Yukihiko,
MatsuyamaSerisawa Kazuyo,
Abe Tsuyoshi,
Matsuda Fuyuhiko,
Suzuki Minoru,
Okino Tatsufumi
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201311175
Subject(s) - biofouling , laurencia , total synthesis , algae , ecotoxicity , natural product , chemistry , red algae , stereochemistry , biology , botany , organic chemistry , biochemistry , membrane , toxicity
Natural antifouling products have been the subject of considerable attention. We screened marine algae for antifouling activity and discovered omaezallenes, the new bromoallene‐containing natural products isolated from the red alga Laurencia sp. Described is the isolation, structure elucidation, and total syntheses of omaezallenes. The relative and absolute configurations of natural omaezallenes were unambiguously established through total synthesis. The antifouling activities and ecotoxicity of omaezallenes were also evaluated.