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Polyoxometalate Clusters Integrated into Peptide Chains and as Inorganic Amino Acids: Solution‐ and Solid‐Phase Approaches
Author(s) -
Yvon Carine,
Surman Andrew J.,
Hutin Marie,
Alex Jennifer,
Smith Brian O.,
Long DeLiang,
Cronin Leroy
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201311135
Subject(s) - polyoxometalate , peptide , amino acid , combinatorial chemistry , chemistry , solid phase synthesis , phase (matter) , peptide synthesis , cluster (spacecraft) , biochemistry , organic chemistry , catalysis , computer science , programming language
General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution‐phase approach, pre‐synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid‐phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain “inorganic” amino acids.