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Copper‐Catalyzed Electrophilic Amination of Heteroarenes and Arenes by CH Zincation
Author(s) -
McDonald Stacey L.,
Hendrick Charles E.,
Wang Qiu
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201311029
Subject(s) - amination , electrophilic amination , chemistry , electrophile , catalysis , organic chemistry , combinatorial chemistry , functional group , polymer
Direct amination of heteroarenes and arenes has been achieved in a one‐pot CH zincation/copper‐catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional‐group compatibility demonstrate its great potential for the synthesis of important and complex amines.