Iron‐Catalyzed C(sp 2 )H and C(sp 3 )H Arylation by Triazole Assistance | Zendy

Gu Qing | Zendy; Al Mamari Hamad H. | Zendy; Graczyk Karolina | Zendy; Diers Emelyne | Zendy; Ackermann Lutz | Zendy

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Iron‐Catalyzed C(sp 2 )H and C(sp 3 )H Arylation by Triazole Assistance

Author(s) -

Gu Qing,

Al Mamari Hamad H.,

Graczyk Karolina,

Diers Emelyne,

Ackermann Lutz

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201311024

Subject(s) - catalysis , chemistry , denticity , combinatorial chemistry , modular design , triazole , scope (computer science) , organic chemistry , computer science , operating system , programming language , crystal structure

Modular 1,2,3‐triazoles enabled iron‐catalyzed CH arylations with broad scope. The novel triazole‐based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user‐friendly iron‐catalyzed C(sp 2 )H functionalizations of arenes and alkenes with excellent chemo‐ and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp 3 )H functionalizations, and proceeds by an organometallic mode of action. The triazole‐assisted CH activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries.

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