EBC‐219: A New Diterpene Skeleton, Crotinsulidane, from the Australian Rainforest Containing a Bridgehead Double Bond | Zendy

Maslovskaya Lidiya A. | Zendy; Savchenko Andrei I. | Zendy; Krenske Elizabeth H. | Zendy; Pierce Carly J. | Zendy; Gordon Victoria A. | Zendy; Reddell Paul W. | Zendy; Parsons Peter G. | Zendy; Williams Craig M. | Zendy

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EBC‐219: A New Diterpene Skeleton, Crotinsulidane, from the Australian Rainforest Containing a Bridgehead Double Bond

Author(s) -

Maslovskaya Lidiya A.,

Savchenko Andrei I.,

Krenske Elizabeth H.,

Pierce Carly J.,

Gordon Victoria A.,

Reddell Paul W.,

Parsons Peter G.,

Williams Craig M.

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201310923

Subject(s) - diterpene , stereochemistry , olefin fiber , chemistry , skeleton (computer programming) , amazon rainforest , rainforest , botany , biology , organic chemistry , anatomy , ecology , polymer

EBC‐219 ( 4 ), isolated from Croton insularis (Baill), was established by spectroscopic and DFT methods as the first member of a new diterpene skeletal class, uniquely defined by the presence of a bicyclo[10.2.1] bridgehead olefin. The proposed biogenetic pathway to 4 from the co‐isolated natural products EBC‐131 ( 1 ), EBC‐180 ( 2 ) and EBC‐181 ( 3 ) is highly likely. EBC‐180 ( 2 ) and EBC‐181 ( 3 ) showed moderate to strong cytotoxic activity against various cancer cell lines.

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