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Rhodium(III)‐Catalyzed Alkenylation Reactions of 8‐Methylquinolines with Alkynes by C(sp 3 )H Activation
Author(s) -
Liu Bingxian,
Zhou Tao,
Li Bin,
Xu Shansheng,
Song Haibin,
Wang Baiquan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310711
Subject(s) - rhodium , catalysis , chemistry , stereoselectivity , catalytic cycle , medicinal chemistry , stereochemistry , organic chemistry
The alkenylation reactions of 8‐methylquinolines with alkynes, catalyzed by [{Cp*RhCl 2 } 2 ], proceeds efficiently to give 8‐allylquinolines in good yields by C(sp 3 )H bond activation. These reactions are highly regio‐ and stereoselective. A catalytically competent five‐membered rhodacycle has been structurally characterized, thus revealing a key intermediate in the catalytic cycle.