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Snapshot of Antidepressants at Work: The Structure of Neurotransmitter Transporter Proteins
Author(s) -
Cuboni Serena,
Hausch Felix
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310567
Subject(s) - neurotransmitter transporter , nortriptyline , transporter , antidepressant , neurotransmitter , drosophila melanogaster , dopamine transporter , dopamine , neurotransmitter receptor , reuptake inhibitor , pharmacology , reuptake , neuroscience , biology , biochemistry , receptor , amitriptyline , gene , serotonin , hippocampus
In the sweet spot : Cocrystal structures of engineered neurotransmitter transporters reveal the binding mode of commonly prescribed antidepressants, providing a basis for a rational drug design for this class of proteins. The picture shows the structure of the dopamine transporter of Drosophila melanogaster in complex with the antidepressant nortriptyline.