Snapshot of Antidepressants at Work: The Structure of Neurotransmitter Transporter Proteins | Zendy

Cuboni Serena | Zendy; Hausch Felix | Zendy

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Snapshot of Antidepressants at Work: The Structure of Neurotransmitter Transporter Proteins

Author(s) -

Cuboni Serena,

Hausch Felix

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201310567

Subject(s) - neurotransmitter transporter , nortriptyline , transporter , antidepressant , neurotransmitter , drosophila melanogaster , dopamine transporter , dopamine , neurotransmitter receptor , reuptake inhibitor , pharmacology , reuptake , neuroscience , biology , biochemistry , receptor , amitriptyline , gene , serotonin , hippocampus

In the sweet spot : Cocrystal structures of engineered neurotransmitter transporters reveal the binding mode of commonly prescribed antidepressants, providing a basis for a rational drug design for this class of proteins. The picture shows the structure of the dopamine transporter of Drosophila melanogaster in complex with the antidepressant nortriptyline.

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