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Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid
Author(s) -
Cheng DaoJuan,
Yan Liang,
Tian ShiKai,
Wu MingYue,
Wang LuXin,
Fan ZiLi,
Zheng ShengCai,
Liu XinYuan,
Tan Bin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310562
Subject(s) - kinetic resolution , enantioselective synthesis , catalysis , axial symmetry , imine , transfer hydrogenation , cascade , chemistry , brønsted–lowry acid–base theory , combinatorial chemistry , chiral resolution , resolution (logic) , kinetic energy , organic chemistry , enantiomer , chromatography , mathematics , physics , computer science , geometry , quantum mechanics , artificial intelligence , ruthenium
A highly efficient strategy for the kinetic resolution of axially chiral BINAM derivatives involving a chiral Brønsted acid‐catalyzed imine formation and transfer hydrogenation cascade process was developed. The kinetic resolution provides a convenient route to chiral BINAM derivatives in high yields with excellent enantioselectivities.