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Inside Back Cover: Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly (Angew. Chem. Int. Ed. 1/2014)
Author(s) -
Ng David Y. W.,
Arzt Matthias,
Wu Yuzhou,
Kuan Seah Ling,
Lamla Markus,
Weil Tanja
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310545
Subject(s) - supramolecular chemistry , enzyme , cover (algebra) , int , chemistry , membrane , self assembly , combinatorial chemistry , stereochemistry , biochemistry , computer science , engineering , organic chemistry , mechanical engineering , operating system , crystal structure
Dynamic supramolecular assembly was used to construct synthetic hybrid enzymes with a protective dendritic shell. In their Communication on page 324 ff. , T. Weil and co‐workers employ boronic acid/salicyl hydroxamate complexation to endow enzymes with pH‐responsive modulated activity and the capability for efficient membrane translocation and localization. The biomimetic strategy explores a unique class of structurally defined biohybrids as enzyme therapeutics.