Inside Back Cover: Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly (Angew. Chem. Int. Ed. 1/2014) | Zendy

Ng David Y. W. | Zendy; Arzt Matthias | Zendy; Wu Yuzhou | Zendy; Kuan Seah Ling | Zendy; Lamla Markus | Zendy; Weil Tanja | Zendy

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Inside Back Cover: Constructing Hybrid Protein Zymogens through Protective Dendritic Assembly (Angew. Chem. Int. Ed. 1/2014)

Author(s) -

Ng David Y. W.,

Arzt Matthias,

Wu Yuzhou,

Kuan Seah Ling,

Lamla Markus,

Weil Tanja

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201310545

Subject(s) - supramolecular chemistry , enzyme , cover (algebra) , int , chemistry , membrane , self assembly , combinatorial chemistry , stereochemistry , biochemistry , computer science , engineering , organic chemistry , mechanical engineering , operating system , crystal structure

Dynamic supramolecular assembly was used to construct synthetic hybrid enzymes with a protective dendritic shell. In their Communication on page 324 ff. , T. Weil and co‐workers employ boronic acid/salicyl hydroxamate complexation to endow enzymes with pH‐responsive modulated activity and the capability for efficient membrane translocation and localization. The biomimetic strategy explores a unique class of structurally defined biohybrids as enzyme therapeutics.

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