Premium
Iridium‐Catalyzed Direct CH Amidation with Weakly Coordinating Carbonyl Directing Groups under Mild Conditions
Author(s) -
Kim Jinwoo,
Chang Sukbok
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310544
Subject(s) - iridium , ketone , acetic acid , chemistry , catalysis , lithium (medication) , carbonate , lithium carbonate , medicinal chemistry , organic chemistry , medicine , ion , ionic bonding , endocrinology
An iridium‐catalyzed direct CH amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives.