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Back Cover: Cell Tracking with Caged Xenon: Using Cryptophanes as MRI Reporters upon Cellular Internalization (Angew. Chem. Int. Ed. 2/2014)
Author(s) -
Klippel Stefan,
Döpfert Jörg,
Jayapaul Jabadurai,
Kunth Martin,
Rossella Federica,
Schnurr Matthias,
Witte Christopher,
Freund Christian,
Schröder Leif
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310518
Subject(s) - xenon , internalization , chemistry , nuclear magnetic resonance , cell , tracking (education) , biophysics , biochemistry , physics , biology , organic chemistry , psychology , pedagogy
Sensitive MRI cell tracking with switchable contrast can be achieved using cryptophanes (CrA) as xenon hosts, as demonstrated by L. Schröder et al. in their Communication on page 493 ff. Cellular uptake of the lipophilic cages, as identified by a unique chemical shift, is determined using hyperpolarized 129 Xe and chemical exchange saturation transfer. Localization of the labeled cells can be achieved with a single Hyper‐CEST acquisition at low micromolar CrA concentrations.