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Highly Chemo‐, Regio‐, and Enantioselective Rhodium‐Catalyzed Cross‐Cyclotrimerization of Two Different Alkynes with Alkenes
Author(s) -
Hara Jun,
Ishida Mana,
Kobayashi Masayuki,
Noguchi Keiichi,
Tanaka Ken
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310336
Subject(s) - rhodium , chemoselectivity , cationic polymerization , enantioselective synthesis , acetylenedicarboxylate , chemistry , catalysis , organic chemistry , medicinal chemistry
Abstract It has been established that a cationic rhodium(I)/( R )‐tol‐binap complex catalyzes the cross‐cyclotrimerization of silylacetylenes, di‐ tert ‐butyl acetylenedicarboxylates, and acrylamides with excellent chemo‐, regio‐, and enantioselectivities. Unsymmetrical alkynoates can also be employed in place of di‐ tert ‐butyl acetylenedicarboxylate for this process, but with reduced chemoselectivity.