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Hydrophobic Actuation of a DNA Origami Bilayer Structure
Author(s) -
List Jonathan,
Weber Michael,
Simmel Friedrich C.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310259
Subject(s) - bilayer , dna origami , amphiphile , lipid bilayer , dna , chemistry , sequence (biology) , membrane , biophysics , pulmonary surfactant , nanotechnology , materials science , polymer , biochemistry , organic chemistry , biology , copolymer
Abstract Amphiphilic compounds have a strong tendency to form aggregates in aqueous solutions. It is shown that such aggregation can be utilized to fold cholesterol‐modified, single‐layered DNA origami structures into sandwich‐like bilayer structures, which hide the cholesterol modifications in their interior. The DNA bilayer structures unfold after addition of the surfactant Tween 80, and also in the presence of lipid bilayer membranes, with opening kinetics well described by stretched exponentials. It is also demonstrated that by combination with an appropriate lock and key mechanism, hydrophobic actuation of DNA sandwiches can be made conditional on the presence of an additional molecular input such as a specific DNA sequence.