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Desymmetrization of Diolefinic Diols by Enantioselective Amino‐thiocarbamate‐Catalyzed Bromoetherification: Synthesis of Chiral Spirocycles
Author(s) -
Tay Daniel Weiliang,
Leung Gulice Y. C.,
Yeung YingYeung
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201310136
Subject(s) - enantioselective synthesis , thiocarbamate , desymmetrization , catalysis , chemistry , organic chemistry , combinatorial chemistry
A facile, efficient, and highly diastereo‐ and enantioselective bromoetherification of diolefinic diols has been developed using an amino‐thiocarbamate catalyst. Further manipulations of the bromoether products enabled entry into a new class of spirocycles which are distinctively lacking in the literature.