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Hydrogenative Dearomatization of Pyridine and an Asymmetric Aza‐Friedel–Crafts Alkylation Sequence
Author(s) -
Wang ShuoGuo,
You ShuLi
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309876
Subject(s) - friedel–crafts reaction , phosphoric acid , chemistry , alkylation , pyridine , organic chemistry , catalysis , sequence (biology) , cascade , combinatorial chemistry , biochemistry , chromatography
Highly efficient synthesis of enantiomerically enriched substituted piperidines has been realized via chiral phosphoric acid catalyzed cascade hydrogenative dearomatization of substituted pyridines and aza‐Friedel‐Crafts reaction in good to excellent yields and enantioselectivity.