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Iridium‐Catalyzed Intermolecular Azide–Alkyne Cycloaddition of Internal Thioalkynes under Mild Conditions
Author(s) -
Ding Shengtao,
Jia Guochen,
Sun Jianwei
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309855
Subject(s) - cycloaddition , alkyne , regioselectivity , intermolecular force , catalysis , azide , iridium , chemistry , click chemistry , photochemistry , combinatorial chemistry , organic chemistry , molecule
An iridium‐catalyzed azide–alkyne cycloaddition reaction (IrAAC) of electron‐rich internal alkynes is described. It is the first efficient intermolecular AAC of internal thioalkynes. The reaction exhibits remarkable features, such as high efficiency and regioselectivity, mild reaction conditions, easy operation, and excellent compatibility with air and a broad spectrum of organic and aqueous solvents. It complements the well‐known CuAAC and RuAAC click reactions.