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Inside Cover: Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon‐Assisted CF Bond CleavageZ308071 (Angew. Chem. Int. Ed. 2/2014)
Author(s) -
Nishimine Takayuki,
Fukushi Kazunobu,
Shibata Naoyuki,
Taira Hiromi,
Tokunaga Etsuko,
Yamano Akihito,
Shiro Motoo,
Shibata Norio
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309818
Subject(s) - enantioselective synthesis , allylic rearrangement , kinetic resolution , hydrosilylation , cinchona , trifluoromethylation , silicon , chemistry , catalysis , stereochemistry , organic chemistry , alkyl , trifluoromethyl
The first kinetic resolution of allyl fluorides was achieved by an enantioselective allylic trifluoromethylation that is catalyzed by a bis(cinchona alkaloid), as described by N. Shibata et al. in their Communication on page 517 ff. Two kinds of chiral fluorinated compounds, which incorporate C*F and C*CF 3 units, respectively, can thus be accessed by a single transformation. Painting: “Mori” (“Forest”) by Mami Shibata; the way through a forest can lead to something exciting.