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Structural Basis for Regulation of Ribosomal RNA 2′‐O‐Methylation
Author(s) -
Hengesbach Martin,
Schwalbe Harald
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309604
Subject(s) - pyrococcus furiosus , ribonucleoprotein , methylation , methyltransferase , rna , ribosomal rna , computational biology , biology , chemistry , genetics , archaea , dna , gene
Methods that interrogate different, yet overlapping structural‐size ranges were integrated to gain high‐resolution information on the Pyrococcus furiosus box C/D ribonucleoprotein complex. The new structure shows how 2′‐O‐methylation of RNA substrates through four active methyltransferases occurs in a strictly sequential manner.