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Nickel‐Catalyzed CH Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes
Author(s) -
Song Weifeng,
Lackner Sebastian,
Ackermann Lutz
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309584
Subject(s) - catalysis , nickel , chemistry , substrate (aquarium) , alkyl , scope (computer science) , alkylation , combinatorial chemistry , medicinal chemistry , organic chemistry , biology , ecology , computer science , programming language
A versatile nickel catalyst allowed for CH alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as CH trifluoroethylations with ample substrate scope.