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Inside Back Cover: Effect of Pressure on the Stability of G‐Quadruplex DNA: Thermodynamics under Crowding Conditions (Angew. Chem. Int. Ed. 51/2013)
Author(s) -
Takahashi Shuntaro,
Sugimoto Naoki
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309404
Subject(s) - dna , cover (algebra) , g quadruplex , chemistry , thermodynamics , biophysics , physics , biology , biochemistry , mechanical engineering , engineering
The effect of pressure on the stability of biomolecules such as DNA is quite unique compared with that of temperature. In their Communication on page 13774 ff., S. Takahashi and N. Sugimoto demonstrate that high pressure causes unfolding of G‐quadruplex DNA. However, the effect was repressed under conditions that mimic those in cells, thereby shedding light on the mechanism of gene expression and novel DNA nanotechnology using pressure.