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Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups
Author(s) -
Egami Hiromichi,
Sodeoka Mikiko
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309260
Subject(s) - trifluoromethylation , functional group , trifluoromethyl , chemistry , combinatorial chemistry , organic chemistry , alkyl , polymer
The trifluoromethyl group is found in many synthetic bioactive compounds, and the difunctionalization of a CC bond, as a powerful strategy for the construction of compounds with various functional groups, has been intensively investigated. Therefore, the difunctionalizing trifluoromethylation of alkenes has attracted growing interest because of the potential of the products as building blocks for bioactive molecules. In this review, we focus on recent advances in the trifluoromethylation of alkenes with concomitant introduction of additional functional groups.