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Diaminocyclopropenylidene Organocatalysts: Beyond N‐Heterocyclic Carbenes
Author(s) -
Con Stephen J.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309256
Subject(s) - intermolecular force , catalysis , organocatalysis , chemistry , carbene , transformation (genetics) , umpolung , combinatorial chemistry , organic chemistry , enantioselective synthesis , molecule , nucleophile , biochemistry , gene
Cyclopropenylidene carbenes have been found to be efficient catalysts for the intermolecular Stetter reaction between aromatic aldehydes and α,β‐unsaturated ketones. In this transformation, the cyclopropenylidene proved superior to more traditional thiazolium‐ and triazolium‐derived carbenes. Preparation and evaluation of a chiral analogue have also been reported.