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Rhodium‐Catalyzed CH Alkynylation of Arenes at Room Temperature
Author(s) -
Feng Chao,
Loh TeckPeng
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309198
Subject(s) - rhodium , hypervalent molecule , alkynylation , catalysis , reagent , chemistry , iodine , combinatorial chemistry , selectivity , organic chemistry
The rhodium(III)‐catalyzed ortho CH alkynylation of non‐electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation.