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Inside Cover: A Chemical Perspective on Transcriptional Fidelity: Dominant Contributions of Sugar Integrity Revealed by Unlocked Nucleic Acids (Angew. Chem. Int. Ed. 47/2013)
Author(s) -
Xu Liang,
Plouffe Steven W.,
Chong Jenny,
Wengel Jesper,
Wang Dong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201309065
Subject(s) - nucleobase , nucleic acid , nucleotide , fidelity , dna , chemistry , rna , polymerase , sugar , ribose , biochemistry , ring (chemistry) , stereochemistry , biology , enzyme , gene , computer science , organic chemistry , telecommunications
An acyclic synthetic RNA analogue was used to reveal the important role of the nucleotide sugar ring in transcriptional fidelity. In their Communication on page 12341 ff. , D. Wang et al. demonstrate that the contribution of the intact nucleotide sugar backbone to the enzymatic efficiency and transcriptional fidelity of RNA polymerase II is significantly stronger than that of the other functional groups of the nucleotide, including the nucleobase and ribose 2′‐OH group.