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The Trifluoromethylating Sandmeyer Reaction: A Method for Transforming CN into CCF 3
Author(s) -
Browne Duncan L.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308997
Subject(s) - trifluoromethylation , reagent , chemistry , combinatorial chemistry , organic chemistry , trifluoromethyl , alkyl
A means to trifluoromethylate : The beneficial properties imparted by the trifluoromethylation of aromatic compounds continue to drive the discovery of novel reagents and reactions for the late‐stage introduction of such moieties. Highlighted here is the recently discovered Sandmeyer trifluoromethylation approach, which now permits aromatic amines to be substrates in a direct trifluoromethylation strategy.