Premium
Inside Back Cover: Development of an Activity‐Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase‐α in Brain (Angew. Chem. Int. Ed. 46/2013)
Author(s) -
Baggelaar Marc P.,
Janssen Freek J.,
van Esbroeck Annelot C. M.,
den Dulk Hans,
Allarà Marco,
Hoogendoorn Sascha,
McGuire Ross,
Florea Bogdan I.,
Meeuwenoord Nico,
van den Elst Hans,
van der Marel Gijsbert A.,
Brouwer Jaap,
Di Marzo Vincenzo,
Overkleeft Herman S.,
van der Stelt Mario
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308975
Subject(s) - in silico , diacylglycerol lipase , diacylglycerol kinase , pharmacophore , computational biology , lipase , chemistry , proteome , docking (animal) , biochemistry , enzyme , biology , protein kinase c , gene , medicine , nursing
In silico screening in combination with activity‐based protein profiling as a strategy for discovering selective hits in complex brain proteome is presented by M. van der Stelt et al. in their Communication on page 12081 ff. A common starting point was used for the generation of both the pharmacophore model and the activity‐based probe. This resulted in the identification of a novel class of diacylglycerol lipase‐α inhibitors with high selectivity in the brain proteome.