Inside Back Cover: Identification of the HcgB Enzyme in [Fe]‐Hydrogenase‐Cofactor Biosynthesis (Angew. Chem. Int. Ed. 48/2013) | Zendy

Fujishiro Takashi | Zendy; Tamura Haruka | Zendy; Schick Michael | Zendy; Kahnt Jörg | Zendy; Xie Xiulan | Zendy; Ermler Ulrich | Zendy; Shima Seigo | Zendy

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Inside Back Cover: Identification of the HcgB Enzyme in [Fe]‐Hydrogenase‐Cofactor Biosynthesis (Angew. Chem. Int. Ed. 48/2013)

Author(s) -

Fujishiro Takashi,

Tamura Haruka,

Schick Michael,

Kahnt Jörg,

Xie Xiulan,

Ermler Ulrich,

Shima Seigo

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201308951

Subject(s) - hydrogenase , cofactor , biosynthesis , guanosine , chemistry , enzyme , derivative (finance) , stereochemistry , biochemistry , financial economics , economics

One reaction step of the biosynthesis of [Fe]‐hydrogenase‐cofactor is elucidated by S. Shima et al. in their Communication on page 12555 ff. A structural genomics approach, in combination with model reactions and thorough product analysis by X‐ray crystallography of the protein–product complexes, revealed that HcgB is the enzyme that catalyzes guanylylpyridinol formation from a 2,4‐dihydroxypyridine derivative and guanosine triphosphate.

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