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Catalyst‐Free Dehydrative α‐Alkylation of Ketones with Alcohols: Green and Selective Autocatalyzed Synthesis of Alcohols and Ketones
Author(s) -
Xu Qing,
Chen Jianhui,
Tian Haiwen,
Yuan Xueqin,
Li Shuangyan,
Zhou Chongkuan,
Liu Jianping
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308642
Subject(s) - alkylation , chemistry , ketone , catalysis , alcohol , organic chemistry , alcohol oxidation , redox , combinatorial chemistry
Direct dehydrative α‐alkylation reactions of ketones with alcohols are now realized under simple, practical, and green conditions without using external catalysts. These catalyst‐free autocatalyzed alkylation methods can efficiently afford useful alkylated ketone or alcohol products in a one‐pot manner and on a large scale by CC bond formation of the in situ generated intermediates with subsequent controllable and selective Meerwein–Pondorf–Verley–Oppenauer‐type redox processes.