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Dirhodium(II) Carboxylate Catalyzed Formation of 1,2,3‐Trisubstituted Indoles from Styryl Azides
Author(s) -
Jones Crystalann,
Nguyen Quyen,
Driver Tom G.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308611
Subject(s) - carboxylate , chemistry , cyclobutanone , catalysis , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , ring (chemistry)
Dirhodium(II)‐carboxylate complexes were discovered to promote the selective migration of acyl groups in trisubstituted styryl azides to form 1,2,3‐trisubstituted indoles. The styryl azides are readily available in three steps from cyclobutanone and 2‐iodoaniline.