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Ruthenium‐Catalyzed Cross‐Dehydrogenative ortho ‐N‐Carbazolation of Diarylamines: Versatile Access to Unsymmetrical Diamines
Author(s) -
Louillat MarieLaure,
Biafora Agostino,
Legros Fabien,
Patureau Frederic W.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308601
Subject(s) - ruthenium , catalysis , intermolecular force , chemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry , photochemistry , organic chemistry , molecule
The dehydrogenative C–N cross‐coupling of unprotected, secondary anilines through ortho ‐N‐carbazolation has been achieved using a Ru catalytic system with O 2 as the terminal oxidant. The reactions proceed in an intermolecular fashion, selectively in the ortho position. Implications for the field of organic synthesis are discussed.