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Hydroxy Functionalization of Non‐Activated CH and CC Bonds: New Perspectives for the Synthesis of Alcohols through Biocatalytic Processes
Author(s) -
Gröger Harald
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308556
Subject(s) - hydroxylation , surface modification , regioselectivity , chemistry , catalysis , biocatalysis , organic chemistry , enzyme , combinatorial chemistry , reaction mechanism
New perspectives through enzymes: Recent breakthroughs have been achieved in the selective hydroxy functionalization of non‐activated CH and CC bonds. Enzymes turned out to be suitable catalysts for the ω‐hydroxylation of (substituted) alkanes and regioselective hydroxylation of aromatic hydrocarbons with atmospheric oxygen as the oxidant, and the asymmetric addition of water to non‐activated alkenes.