Premium
Synthesis of 6‐Alkylated Phenanthridine Derivatives Using Photoredox Neutral Somophilic Isocyanide Insertion
Author(s) -
Jiang Heng,
Cheng Yuanzheng,
Wang Ruzhi,
Zheng Mengmeng,
Zhang Yan,
Yu Shouyun
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308376
Subject(s) - phenanthridine , isocyanide , alkylation , iridium , photocatalysis , scope (computer science) , chemistry , combinatorial chemistry , computer science , photochemistry , organic chemistry , catalysis , programming language
Bring to light : The first visible‐light‐promoted somophilic isocyanide insertion occurs using an iridium photocatalyst. This efficient synthetic approach provides a rapid entry to 6‐alkylated phenanthridine derivatives (see scheme). The reactions proceed at room temperature in good to excellent yields with broad substrate scope and under environmentally friendly conditions.