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Inside Back Cover: Aptamer‐Guided Caging for Selective Masking of Protein Domains (Angew. Chem. Int. Ed. 45/2013)
Author(s) -
Rohrbach Falk,
Schäfer Florian,
Fichte Manuela A. H.,
Pfeiffer Franziska,
Müller Jens,
Pötzsch Bernd,
Heckel Alexander,
Mayer Günter
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308371
Subject(s) - aptamer , cover (algebra) , linker , thrombin , chemistry , nanotechnology , biophysics , computer science , materials science , biology , microbiology and biotechnology , engineering , platelet , immunology , mechanical engineering , operating system
The light‐controlled regulation of the activity of protein subdomains is possible with a new approach termed apta‐caging, the development of which is reported by A. Heckel, G. Mayer et al. in their Communication on page 11912 ff. The aptamer HD1 is bound by a photocleavable linker to the regulatory Exosite I of thrombin. As a result, the thrombin activity can be spatially and temporally controlled by light irradiation. Owing to the large interaction area of the aptamer mask, no knowledge of the protein structure is required.