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Back Cover: Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3 (Angew. Chem. Int. Ed. 44/2013)
Author(s) -
Neubauer Stefanie,
Rechenmacher Florian,
Beer Ambros J.,
Curnis Flavio,
Pohle Karolin,
D'Alessandria Calogero,
Wester HansJürgen,
Reuning Ute,
Corti Angelo,
Schwaiger Markus,
Kessler Horst
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308315
Subject(s) - peptidomimetic , positron emission tomography , integrin , angiogenesis , fibrosarcoma , cover (algebra) , in vivo , chemistry , cancer research , preclinical imaging , medicine , pathology , nuclear medicine , receptor , biochemistry , peptide , biology , mechanical engineering , microbiology and biotechnology , engineering
In vivo tumor imaging by positron emission tomography (PET) is possible following the functionalization of α5β1 or αvβ3 subtype‐selective integrin antagonists with NODAGA. H. Kessler and co‐workers also show in their Communication on page 11656 ff. that these peptidomimetics are able to block bFGF‐ and VEGF‐stimulated angiogenesis in a rat aortic ring (RAR) assay, and exert anti‐tumor effects in a fibrosarcoma model in mice. (Picture designed by Philipp Ganthaler.)