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Cover Picture: Binding of a Designed Anti‐Cancer Drug to the Central Cavity of an RNA Three‐Way Junction (Angew. Chem. Int. Ed. 44/2013)
Author(s) -
Phongtongpasuk Siriporn,
Paulus Susann,
Schnabl Joachim,
Sigel Roland K. O.,
Spingler Bernhard,
Han Michael J.,
Freisinger Eva
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308234
Subject(s) - cover (algebra) , supramolecular chemistry , rna , chemistry , solid state , stereochemistry , crystallography , biophysics , nanotechnology , combinatorial chemistry , materials science , biochemistry , biology , engineering , gene , mechanical engineering , crystal structure
Recognition and stabilization of an RNA three‐way junction by a supramolecular di‐iron(II) cylindrical complex is described by R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger et al. in their Communication on page 11513 ff. This potential anti‐cancer metal‐based drug fits perfectly into the central RNA core and stabilizes this architecture in the solid state as well as under native gel conditions. (Cover picture: Joachim Schnabl.)